Mach III and DeskCNC

I have been debating on which of these machine controllers I want to
use. My problem is that I really like the Cam and the digitizing that
DeskCNC offers, but I am going to run it on a Shoptask machine. I
really need a lathe contoller. It doesnt have to be a fancy one, but
I need to be able to cut threads. My question is this, can I use more
than one type of controller with the DeskCnc hardware? If so, which
ones are compatible?
William